Five companies met our criteria from the five 10-K annual reports filed with the SEC on 28 October 2026. To qualify, a company must have filed an annual 10-K report on the target date and have a prior-year 10-K available for a direct year-over-year comparison.
SEC What Changed Methodology
Each company is scored on how similar its current annual filing text is to the prior year. Scores run from 0 to 1 — a score of 1 means the language is essentially unchanged; a lower score means more has changed. We flag three sections that carry the most disclosure signal: Business, Risk Factors, and MD&A. Recent research suggests that lower scores indicate that a company has made significant changes to their filings, these changes are often buried in the filings. If a company was to report positive news, they would likely do so in the form of a press release or statement on their website. The large changers have often underperformed in the market, while the stable-language filers have earned positive abnormal returns.
Key Takeaways
- Zedge, Inc. (High) — Zedge is repositioning itself from a consumer app company into an AI-enabled creator platform, and DataSeeds is the key new growth bet.
- UNIFIRST CORP (Medium) — UniFirst is signaling a wider set of operational and cost risks, with labor, environmental, and systems execution now more prominently on the radar.
- BriaCell Therapeutics Corp. (Medium) — BriaCell is signaling better short-term funding capacity, but the new filing also makes clear that dilution and execution risk remain central to the story.
- Vanguard Green Investment Ltd (Medium) — The key signal is that Vanguard is abandoning a now-worthless legacy asset while trying to reinvent itself as a green finance platform, with execution risk still very high.
- Odyssey Health, Inc. (Low) — This filing is mostly a housekeeping update, but it confirms Odyssey remains a pre-commercial medical developer with modestly stronger cyber controls and no change in its core execution risk.
Ranking Table
| Rank | Company | CIK | Full Filing Similarity | Business Similarity | Risk Factors Similarity | MD&A Similarity | Most Changed Section | Assessment |
|---|---|---|---|---|---|---|---|---|
| 1 | Zedge, Inc. | 1667313 | 0.994 | 0.972 | 0.993 | 0.994 | Business | high |
| 2 | UNIFIRST CORP | 717954 | 0.994 | 0.982 | 0.969 | 0.983 | Risk Factors | medium |
| 3 | BriaCell Therapeutics Corp. | 1610820 | 0.996 | 0.994 | 0.996 | 0.997 | Business | medium |
| 4 | Vanguard Green Investment Ltd | 1746119 | 0.995 | 0.999 | 0.999 | 0.999 | Business | medium |
| 5 | Odyssey Health, Inc. | 1626644 | 0.994 | 0.997 | 0.99 | 0.998 | Risk Factors | low |
Zedge, Inc.
| Rank | 1 |
|---|---|
| Lowest similarity section | Business |
| Assessment | high |
| SEC filings | 2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text) |
Zedge’s business description now centers on creator communities and a new AI data business, DataSeeds.AI, rather than just its consumer marketplace and photo game. Management is signaling that it wants to monetize its creator base in more ways, including selling rights-cleared datasets for AI training and robotics use cases. That is a bigger strategic move than a routine wording update, but it also brings new operational and legal risks.
Main Changes
- The company rewrote its business description to say it now "build[s] and operate[s] creator communities" across Zedge Marketplace and GuruShots, instead of mainly describing a digital content marketplace and games business.
- Zedge added DataSeeds.AI, a new business-to-business offering that sells "rights-cleared" multimodal datasets, including images, video, audio and egocentric video for robotics training, to AI model developers, tech companies and robotics manufacturers.
- The filing now says the content foundation for DataSeeds comes from Zedge’s proprietary creator communities and that the company has delivered datasets at scale, but to date has served only a small number of customers.
- The business section also reframed pAInt as part of a broader AI creation suite and reduced emphasis on the prior standalone app description, while updating the company to 19.3 million monthly active users across Zedge Marketplace and GuruShots.
Watch Items
- DataSeeds is a meaningful strategic expansion into AI data licensing, which could open a new revenue stream but also introduces customer concentration and execution risk.
- The shift toward AI and rights-cleared datasets raises legal and sourcing questions around contributor permissions, ownership claims and whether the company can scale supply fast enough.
- The updated user and product framing suggests Zedge is leaning harder on its creator ecosystem to monetize beyond consumer apps, which could improve growth if adoption sticks.
Important Filing Changes
Added: The filing adds risks that content owners may refuse AI training use, DataSeeds demand may be limited, and customer concentration could hurt results.
21 Our efforts to develop and expand our content licensing business exposes us to a number of risks that could limit our ability to grow, achieve commercial success, and maintain our overall, business, results of operations, and financial condition. [No corresponding passage in the 2025 filing.] Contributors may choose not to provide their content for licensing purposes, which could prevent us from scaling our licensing business.
13 ● Our efforts to develop and expand DataSeeds, our business-to-business data offering, expose us to a number of risks that could limit our ability to grow, achieve commercial success, and maintain our business, results of operations, and financial condition. Contributors may choose not to make their content available for AI training and related uses, which could prevent us from scaling DataSeeds. ● Our catalog may not contain the types of content that our customers seek, which could limit demand for DataSeeds. ● We provide DataSeeds datasets and services through discrete projects rather than under recurring contracts, and our results may fluctuate significantly from period to period. ● A downturn in the AI market could reduce demand for our datasets and services and adversely affect our growth prospects. ● Sales of DataSeeds dataset and service offerings have been concentrated among a small number of customers, and a reduction in their spending, or our inability to broaden our customer base, could materially reduce our revenue. ● If we fail to maintain and enhance our various brands, or if we incur excessive expenses in this effort, our business, results of operations and prospects may be materially and adversely affected. ● We may not be able to effectively manage our growth or implement our future business strategies, in which case our business and results of operations may be materially and adversely affected. ● Substantially all of our personnel are located in Israel and Lithuania, and armed conflict or instability affecting either country could disrupt our operations and our ability to serve our customers. ● We recently changed our chief executive officer, and the transition in senior leadership could disrupt our business. ● Privacy, data protection and emerging artificial intelligence laws expose us to sanctions, litigation and increased costs of compliance. ● Laws regulating online platforms and digital content services may impose additional compliance obligations and penalties on us. ● Content depicting identifiable individuals may expose us to privacy, right of publicity, artificial intelligence, and other data processing-related laws, including with respect to alleged processing of biometric data, geographic information, and minors’ information, as well as to evolving regulatory obligations, including, for example, with respect to data brokers, and non-compliance could result in liability. ● Our business depends on our ability to collect and effectively use data to serve relevant advertising, deliver suitable content, and identify prospective advertisers, and any limitation on the collection and use of this data could significantly diminish the value of our services, cause us to lose advertisers, make us less attractive to prospective advertisers, and harm our revenues. ● Any significant system or network disruption or cyberattack could have a material adverse effect on our business prospects and results of operations. ● We are controlled by our majority stockholder, which limits the ability of other stockholders to affect our management. ● If we face intellectual property infringement claims arising from content offered through Zedge Marketplace, GuruShots, or DataSeeds, or are unable to license, acquire or otherwise obtain access to compelling content and services at reasonable cost, or if we do not develop or commission compelling content of our own, the number of users may not grow as anticipated, or may decline, or users’ level of engagement may decline, all or any of which could materially harm our business and operating results. ● Our ability to grant rights to customers may be limited by the rights we obtain from contributors and production partners, and defects in rights associated with content already used to train AI models may be difficult or impossible to remedy. 14 RISKS RELATED TO OUR BUSINESS AND INDUSTRY If we fail to keep up with rapid technological changes in the internet, smartphone industries, and artificial intelligence (“AI”), and adapt our products and services accordingly, our results of operations and future growth may be adversely affected.
Removed: The filing no longer includes the Article 17 liability exemption regime for OCSSPs and its cooperation requirements.
This means that OCSSPs will be liable for copyright-protected material uploaded by users and must obtain authorization (i.e., a license) from the relevant rightsholders. However, Article 17 effectively creates a new liability exemption regime for OCSSPs (albeit a more onerous one than is currently provided by the E-Commerce Directive) under which OCSSPs will not be liable for the copyright-protected works that they communicate to the public provided that they cooperate with rightsholders by: ● making best efforts to obtain the necessary authorization (i.e., a license); ● expeditiously taking down or disabling access to content upon receiving a sufficiently substantiated notice to do so by rightsholders (i.e., similar to the existing ‘notice and take-down’ requirements); ● making best efforts to prevent future uploads of content in respect of which they have received a notice from rightsholders pursuant to the previous requirement (i.e., a ‘notice and stay down’ requirement); and ● making best efforts, in accordance with high industry standards of professional diligence, to ensure the unavailability of specific works in respect of which rightsholders have provided the ‘relevant and necessary information.’ The article also extends any licenses granted to OCSSPs to their users, as long as those users are not acting “on a commercial basis.” Our increased use of artificial intelligence (AI), including generative AI, in our product offerings presents additional risks. For example, uncertain legal and regulatory treatment around the provision and use of such technologies, for example in the areas of privacy and intellectual property, may create increased and uncertain litigation exposure, the possibility of regulatory scrutiny, costly compliance requirements and limit or prohibit certain of our product offerings.
[No corresponding passage in the 2026 filing’s MD&A section.]
Added: The filing adds regulatory developments on AI, the EU AI Act, UK subscription rules, cybersecurity and data privacy, and child protection rules.
New laws and regulations, changes in existing laws and regulations or the interpretation of them, our introduction of new products, or an extension of our business into new areas could increase our future compliance costs, make our products and services less attractive to our users, introduce litigation exposure, or cause us to change or limit our business practices. [No corresponding passage in the 2025 filing.] We may incur substantial expenses to comply with laws and regulations or defend against a claim that we have not complied with them.
New laws and regulations, changes in existing laws and regulations or the interpretation of them, our introduction of new products, or an extension of our business into new areas could increase our future compliance costs, make our products and services less attractive to our users, introduce litigation exposure, or cause us to change or limit our business practices. Particular regulatory developments of note consist of the evolving regulatory landscape for AI, parts of the EU Artificial Intelligence Act now being in force, including provisions around prohibited AI and transparency requirements, new subscription rules in the UK which come into force in January 2027 and will provide additional rights to users in relation to subscriptions, including more notices regarding cancellation and rights to withdraw, which could lead to more churn, new rules impacting cybersecurity and data privacy, and emerging expansion of rules to protect children from certain digital services around the world. We may incur substantial expenses to comply with laws and regulations or defend against a claim that we have not complied with them.
UNIFIRST CORP
| Rank | 2 |
|---|---|
| Lowest similarity section | Risk Factors |
| Assessment | medium |
| SEC filings | 2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text) |
UniFirst’s updated risk factors are more detailed and more explicit about the pressures it faces. The company now calls out environmental liabilities, labor unionization campaigns, supply-chain disruption, inflation in energy and labor, and the risk that its ERP and IT systems could fail or be attacked. Overall, the filing reads as a broader and more specific risk profile rather than a major strategic reset.
Main Changes
- The risk factor list was expanded to spell out more specific operating threats, including "uncertainties regarding any existing or newly-discovered expenses and liabilities related to environmental compliance and remediation" and "any adverse outcome of pending or future contingencies or claims."
- UniFirst added a broader labor risk tied to "our ability to preserve positive labor relationships and avoid becoming the target of corporate labor unionization campaigns that could disrupt our business."
- The company also sharpened supply-chain and cost language, citing dependence on third parties for raw materials, possible disruption from "the conflict between Russia and Ukraine," and pressure from "high price levels of natural gas, electricity, fuel and labor."
- The filing now explicitly flags execution risk around "our ability to properly and efficiently design, construct, implement and operate a new enterprise resource planning (ERP) computer system" and "interruptions or failures of our information technology systems, including as a result of cyber-attacks."
Watch Items
- Environmental and remediation exposure can create unplanned cash costs and longer-tail liabilities that may weigh on margins.
- The added unionization and labor-cost language suggests management sees employee relations and wage inflation as a more material operating risk.
- ERP and cyber risk disclosures point to execution and service-disruption risk as the company modernizes systems.
Important Filing Changes
Added: The new filing adds merger-related risks, including a $213,300,000 termination fee and uncertainty about alternative transactions.
[No corresponding passage in the 2025 filing’s Risk Factors section.]
If the Mergers are not completed, our ongoing business, financial condition, financial results and stock price could be materially adversely affected, and we would forego any benefit of completing the Mergers. Without realizing any of the benefits of having completed the Mergers, we will be subject to a number of risks, including the following: • the market price of our stock could decline to the extent that the current market price reflects a market assumption that the transaction will be completed; • we could owe Cintas a termination fee of $213,300,000 if the Merger Agreement were terminated under specified circumstances; • if the Merger Agreement is terminated and the UniFirst Board of Directors seeks another business combination, UniFirst shareholders cannot be certain that UniFirst will be able to find a party willing to enter into a transaction on terms equivalent to or more attractive than the terms in the Merger Agreement; • time and resources committed by our management to matters relating to the Mergers could otherwise have been devoted to pursuing other beneficial opportunities; • we may experience negative reactions from the financial markets or from customers, suppliers or employees; • we will be required to pay our costs relating to the Mergers, such as legal, accounting, financial advisory and printing fees, whether or not the Mergers are completed; and • litigation related to any failure to complete the Mergers or related to any enforcement proceeding commenced against us to perform our obligations pursuant to the Merger Agreement. The materialization of any of these risks could adversely impact our ongoing business, financial condition, financial results and stock price.
Added: The new filing adds the merger consideration for each share of Common Stock: $155.00 in cash and 0.7720 Cintas shares.
[No corresponding passage in the 2025 filing’s Business section.]
1 Merger Agreement On March 10, 2026, we entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Cintas Corporation (“Cintas”), Bruin Merger Sub I, Inc., a wholly owned subsidiary of Cintas (“Merger Sub Inc.”), and Bruin Merger Sub II, LLC, a wholly owned subsidiary of Cintas (“Merger Sub LLC”). Pursuant to the terms and conditions of the Merger Agreement, at the effective time of the merger of the Company with and into Merger Sub Inc., each share of (i) our common stock, par value $0.10 per share, and (ii) our Class B common stock, par value $0.10 per share, (clauses (i) and (ii), our “Common Stock”) issued and outstanding immediately prior to the effective time of this merger (other than shares of our Common Stock held in our treasury or held directly by a subsidiary of the Company, Cintas, Merger Sub Inc. or Merger Sub LLC) will convert into the right to receive: $155.00 in cash and 0.7720 shares of fully paid and nonassessable Cintas common stock (the “Merger Consideration”). No fractional shares of Cintas common stock will be issued in this merger, and holders of our Common Stock will receive cash in lieu of any fractional shares of Cintas common stock.
Added: The new filing adds Merger Agreement termination timing and extension dates through September 10, 2027.
[No corresponding passage in the 2025 filing’s Risk Factors section.]
Cintas and UniFirst have been working cooperatively with the FTC and will continue to do so. Also, either Cintas or UniFirst may terminate the Merger Agreement (as defined in Note 1, “ Summary of Significant Accounting Policies ”) if the Mergers have not been consummated on or before 5:00 p.m. (New York, New York, United States time) on January 10, 2027 (or, in certain circumstances, as such date may be extended to May 10, 2027 or September 10, 2027 pursuant to the Merger Agreement), except that this right to terminate the Merger Agreement is not available to any party that has materially breached any of its obligations under the Merger Agreement if such breach has been the principal cause of or principally resulted in the failure of the closing to have occurred on or before such date. If the Mergers are not completed, our ongoing business, financial condition, financial results and stock price could be materially adversely affected, and we would forego any benefit of completing the Mergers.
BriaCell Therapeutics Corp.
| Rank | 3 |
|---|---|
| Lowest similarity section | Business |
| Assessment | medium |
| SEC filings | 2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text) |
BriaCell’s filing puts much more emphasis on funding and pipeline execution than the prior year. It says the company raised roughly $50.9 million in fiscal 2025, then adds a January 2026 offering that brought in another $30.0 million gross, while also laying out more specific development milestones for BriaPro and its kinase inhibitor program. The overall message is that the company has more cash to work with, but it remains heavily reliant on equity financing and still faces meaningful dilution risk.
Main Changes
- The Business section now says the company completed several financings in fiscal 2025, raising about $50.9 million in gross proceeds, and says this "significantly bolstered" capital to fund clinical trials, pipeline programs, and operations.
- A new January 2026 public offering is described in detail: 5,366,726 units were sold for about $30.0 million gross, including 4,327,530 common shares and 1,039,196 pre-funded warrants, plus warrants exercisable at $6.93 per share.
- The company added a more specific development roadmap for BriaPro, saying it expects to screen multi-specific binding reagents, select at least one candidate for IND-enabling studies, and start human clinical studies in the first half of 2025; it also says protein kinase C delta inhibitor clinical studies are expected in the second half of 2025.
- The filing repeats and expands the share consolidation disclosure, noting a 1-for-15 reverse split effective January 24, 2025 and a second 1-for-10 consolidation effective August 25, 2025.
Watch Items
- The added financing detail signals improved near-term liquidity, but also highlights continued dependence on equity capital and potential dilution from warrants and future raises.
- The more explicit clinical timeline suggests management is trying to show execution visibility, which matters for a preclinical/clinical-stage biotech with no commercial revenue.
- The repeated reverse splits underscore ongoing pressure on the share price and may indicate the company is still managing Nasdaq listing and capital-markets constraints.
Important Filing Changes
Reworded: The license is now described as being sold to BriaPro under a definitive purchase agreement, including associated assets.
This program represents a diversification of BriaCell’s pipeline into next-generation antibody modalities and underscores the Company’s leadership in immuno-oncology innovation. 19 License Agreements On August 4, 2022, BriaCell announced that it has secured an exclusive license from University of Maryland, Baltimore County (UMBC) to develop and commercialize Soluble CD80 (sCD80) as a biologic agent for the treatment of cancer. Under the terms of the agreement, BriaCell has the worldwide rights to develop and commercialize sCD80, while UMBC maintains ownership of the patents (the “UMBC Licensing Agreement”).
This program represents a diversification of BriaCell’s pipeline into next-generation antibody modalities and underscores the Company’s leadership in immuno-oncology innovation. On February 18, 2026, the Company and BriaPro, announced that we have entered into a definitive purchase agreement (the “ Purchase Agreement ”) pursuant to which BriaPro has agreed to purchase BriaCell’s exclusive license to develop and commercialize Soluble CD80 (“ sCD80 ”) as a biologic agent for the treatment of cancer and other associated assets (the “ Transaction ”). On October 6, 2026, BriaCell and BriaPro announced that four abstracts featuring preclinical research from their respective immunotherapy programs have been selected for poster presentations at the Society for Immunotherapy of Cancer (SITC) 41st Anniversary Annual Meeting, taking place November 4-8, 2026, in Phoenix, AZ.
Removed: The filing drops the risk that a post-August 2025 share consolidation could trigger immediate delisting without a compliance period.
Under the Nasdaq Excessive Reverse Stock Split Rule, if a company’s common shares fail to meet the minimum bid price requirement and the company has effected a reverse stock split within the prior one-year period, it will not be eligible for any compliance period to address a bid price deficiency. Accordingly, if our common shares fall out of compliance with the minimum bid requirement within a one-year period following our August 2025 share consolidation, we will be issued a delisting determination rather than being granted a compliance period. Under these circumstances, we could appeal the delisting determination to a Hearings Panel, during which time any suspension or delisting action will be stayed.
[No corresponding passage in the 2026 filing’s Risk Factors section.]
Added: The filing adds patent details for Soluble CD80 and a February 6, 2025 PCT patent application.
On March 29, 2024, BriaCell and the National Cancer Institute (NCI) filed an international patent application under the PCT directed to engineered mammalian dendritic cells that express exogenous MHC class II alleles for the development of innovative dendritic cell-based immunotherapeutic strategies. [No corresponding passage in the 2025 filing.] Soluble CD80 The patents held under UMBC Licensing Agreement are as follows: USPN 8,956,619 B2 USPN 9,650,429 B2 USPN 10,377,810 B2 Employees As of the date of this filing, we had twenty-two full-time employees, located in various US states including: NY, FL, PA, SC, NV and NJ.
On March 29, 2024, BriaCell and the National Cancer Institute (NCI) filed an international patent application under the PCT directed to engineered mammalian dendritic cells that express exogenous MHC class II alleles for the development of innovative dendritic cell-based immunotherapeutic strategies. Soluble CD80 The patents held under UMBC Licensing Agreement are as follows (recently tranferred form Briacell to BriaPro): USPN 8,956,619 B2 USPN 9,650,429 B2 USPN 10,377,810 B2 On February 6, 2025, BriaCell filed an international patent application under the PCT directed to whole-cell cancer vaccines expressing highly immunogenic post-translational modified antigens. The PCT application (PCT/US2025/014759) published on August 14, 2025 as International Publication No.
Vanguard Green Investment Ltd
| Rank | 4 |
|---|---|
| Lowest similarity section | Business |
| Assessment | medium |
| SEC filings | 2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text) |
Vanguard Green Investment says its patent no longer has economic value and has been fully written off. At the same time, the company is leaning harder into a new green finance strategy centered on ESG, carbon trading, and related financial services. The filing suggests a business model reset, but there is still no evidence of operating revenue from the new direction.
Main Changes
- The company added a new disclosure that it "decided to write off the entire patent" as of April 30, 2026 because the asset "has no further economic benefit" to the business.
- The business description continues to shift away from the prior beauty and wellness framing and toward a new focus on "promoting green finance" and ESG-related services.
- The future plan now emphasizes "carbon trading, carbon pledge financing, and carbon custody" as the core service set, rather than the earlier product-oriented operating model.
Watch Items
- Writing off the patent suggests management no longer sees the legacy asset as commercially useful, which can be a sign the old business line is being abandoned or de-emphasized.
- The ESG and green finance pivot is a strategic repositioning, but investors should watch whether the company can actually build revenue in carbon-related financial services.
- The filing still says the company has not generated ordinary-course revenue, so the new strategy remains largely aspirational rather than proven.
Important Filing Changes
No material section-level wording change was large enough to quote from the compared sections.
Odyssey Health, Inc.
| Rank | 5 |
|---|---|
| Lowest similarity section | Risk Factors |
| Assessment | low |
| SEC filings | 2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text) |
Odyssey Health made a small but notable cybersecurity update by adding that a managed security services provider helps with extra protections such as malware and network security tools. The rest of the risk disclosure remains largely unchanged, with no new cyber incidents reported. In the business section, the company sharpened its description of a development-stage medical device strategy and reiterated that it is not yet selling products and still needs regulatory clearance.
Main Changes
- The cybersecurity section now says the company uses a "managed security services provider" to help implement extra controls, including "malware protection and network security tools."
- The board oversight disclosure was reorganized, but the core message stayed the same: the Board and the Corporate Governance and Nominating Committee oversee cybersecurity risk, and the committee reports to the board annually.
- The business description was tightened to emphasize creating or acquiring assets and technologies that address an "unmet medical need," and it now says the company will complete clinical trials and manufacture products under FDA regulations.
- The company also clarified it is "not currently selling or marketing any products" and that U.S. and international commercialization will require regulatory clearance or approval.
Watch Items
- The added managed-security language suggests a modest upgrade in cyber controls, which matters because the company still relies on digital systems despite being early stage.
- The business wording reinforces a development-stage model with no current product sales, so execution risk remains tied to clinical progress and regulatory approvals.
- The OTCID listing reference and continued lack of commercial products underscore limited operating scale and likely ongoing financing dependence.
Important Filing Changes
Added: A new default can trigger acceleration, 150% default amounts, 16% default interest, and termination of the Maintenance Agreement.
[No corresponding passage in the 2025 filing’s Risk Factors section.]
They do not apply to any other event of default under the notes, to any payment default occurring after October 23, 2026, including a failure to repay the notes at their extended maturity date, or to any failure to maintain the Reserved Amount after January 31, 2027. If an event of default not covered by the Global Amendment occurs and is not waived by Mast Hill, Mast Hill would be entitled to, among other remedies, accelerate all amounts outstanding under the Maintenance Note and the Master Note (including a default amount equal to the outstanding principal and accrued interest, multiplied by 150%), impose default interest at a rate of 16% per annum, and terminate the Maintenance Agreement. Termination of the Maintenance Agreement would eliminate the fee income that we have used to offset amounts owed under the tranches of the Master Note.
Added: The notes’ maturity was extended to January 31, 2027, and Mast Hill granted limited waivers for specified defaults.
[No corresponding passage in the 2025 filing’s Risk Factors section.]
On October 23, 2026, we entered into a Global Amendment with Mast Hill (the “Global Amendment”) covering all four of our promissory notes held by Mast Hill, including each tranche funded under the Master Note. Under the Global Amendment, (i) the maturity date of each of the notes was extended to January 31, 2027; (ii) Mast Hill agreed to a one-time waiver of any event of default under Section 3.1 or Section 3.2 of the notes that occurred on or before October 23, 2026, which includes our nonpayment of the August 2025 note at maturity and our failure to maintain the Reserved Amount; and (iii) Mast Hill agreed to a one-time waiver of any event of default under Section 3.2 of the notes that may occur from October 23, 2026 through January 31, 2027 as a result of our failure to satisfy the Reserved Amount. The waivers are limited to the events of default described above.
Reworded: The risk factor list adds going-concern doubt, possible operational curtailment, and indebtedness maturing in the near term.
Therefore, you should not place undue reliance on our forward-looking statements. You should understand that the following important factors could affect our future results and could cause those results or other outcomes to differ materially from those expressed or implied in our forward-looking statements: · our limited operating history and lack of revenue, on which to evaluate our ability to achieve our business objective and projected cash needs and our expected future revenues, operations and expenditures; · our potential ability to obtain additional financing on favorable terms; · our public securities’ potential liquidity and trading; · the extent to which we acquire or invest in businesses, products, and technologies; the scope, progress, results and costs of our clinical trials for our drug candidates and medical devices; · the scope, progress, results and costs of our clinical trials for our drug candidates and medical devices; · our ability to successfully integrate our acquired products and technologies into our business, including the possibility that we will not fully realize the expected benefits of the transactions will not be fully realized by us or may take longer to realize than expected; · the safety and efficacy of our product candidates; · the progress and timing of clinical trials; · the costs, timing, and outcome of regulatory review of our product candidates; · the timing of submissions to, and decisions made by the U.S. Food and Drug Administration (“FDA”) and other regulatory agencies, related to our product candidates to the satisfaction of the FDA and such other regulatory agencies; · our ability to obtain, maintain and successfully enforce adequate patent and other intellectual property or regulatory exclusivity protection of our product candidates and the ability to operate our business without infringing on the intellectual property rights of others; · the costs of preparing, filing, and prosecuting patent applications and maintaining, enforcing, and defending intellectual property-related claims; · the emergence of competing technologies and other adverse market developments; · changes in accounting standards; and · the other risks and uncertainties discussed herein and in our other filings with the SEC.
Therefore, you should not place undue reliance on our forward-looking statements. You should understand that the following important factors could affect our future results and could cause those results or other outcomes to differ materially from those expressed or implied in our forward-looking statements: · our limited operating history and lack of revenue, on which to evaluate our ability to achieve our business objective and projected cash needs and our expected future revenues, operations and expenditures; · our potential ability to obtain additional financing on favorable terms; · the substantial doubt about our ability to continue as a going concern; · If we are unsuccessful in raising additional financing, we may need to curtail, discontinue, or cease operations; · a substantial portion of our indebtedness is scheduled to mature in the near term, and we lack sufficient funds to satisfy these obligations; · the restructuring of our indebtedness or seeking relief under the U.S. Bankruptcy Code, either of which could result in substantial dilution to our existing stockholder’s or the loss of their entire investment; · our public securities’ potential liquidity and trading; · the extent to which we acquire or invest in businesses, products, and technologies; the scope, progress, results and costs of our clinical trials for our drug candidates and medical devices; · the costs, timing, and outcome of regulatory review of our product candidates; 35 · the timing of submissions to, and decisions made by the U.S.
Why SEC Filing Changes Matter
Research by Cohen et al. (Lazy Prices, 2020) — using the complete history of SEC filings from 1995 to 2014 — shows that when firms make active changes to their annual disclosures, those changes convey an important signal about future operations and returns. A portfolio that shorted "changers" and bought "non-changers" earned over 22% per year in annual alpha historically. Changes to the Risk Factors section, Business description, and language referring to the executive team were especially informative. Critically, these returns accrued gradually as information was later revealed through news and earnings — not at the time of filing — suggesting many investors remain inattentive to these simple, public signals. This snapshot is a starting point for deeper investigation, not a buy or sell recommendation.
For more like this, see the full SEC What Changed archive, browse more equity research reports, or subscribe to Quantitative Research Notes for new filing-change alerts as soon as they publish.

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