Biomerica (BMRA) 10-K: Business Changes Lead 31 August 2026 Filing Roundup

Biomerica (BMRA)’s Business section changed the most among 5 companies that filed 10-Ks on 31 August 2026, each compared against its prior-year filing.

Desk:
SEC What Changed — 31 August 2026 10-K filing snapshot
BMRA-32.35%
GLGI-78.26%
SMCI-10.40%
STME-18.52%
CYDY-26.91%

Five companies met our criteria from the six 10-K annual reports filed with the SEC on 31 August 2026. To qualify, a company must have filed an annual 10-K report on the target date and have a prior-year 10-K available for a direct year-over-year comparison. A prior-year filing was not available for Elventix Technology Corp, so it is excluded from the ranking.

SEC What Changed Methodology

Each company is scored on how similar its current annual filing text is to the prior year. Scores run from 0 to 1 — a score of 1 means the language is essentially unchanged; a lower score means more has changed. We flag three sections that carry the most disclosure signal: Business, Risk Factors, and MD&A. Recent research suggests that lower scores indicate that a company has made significant changes to their filings, these changes are often buried in the filings. If a company was to report positive news, they would likely do so in the form of a press release or statement on their website. The large changers have often underperformed in the market, while the stable-language filers have earned positive abnormal returns.

Key Takeaways

  • BIOMERICA INC (High) — Biomerica’s key message is that survival now depends on raising capital and converting new service revenue before cash runs too low.
  • GREYSTONE LOGISTICS, INC. (High) — Greystone is signaling tighter liquidity and heavier reliance on lender and insider support to keep funding the business.
  • Stimcell Energetics Inc. (High) — Stimcell is spending more to revive eBalance, but the filing still shows no revenue, heavier losses, and ongoing dependence on outside financing.
  • Super Micro Computer, Inc. (Medium) — The biggest new issue is that Super Micro’s Malaysia tax benefit is not guaranteed, and losing it would directly raise taxes and reduce earnings power.
  • CytoDyn Inc. (Low) — This filing points to incremental compliance and operating updates, not a material change in CytoDyn’s strategy or risk profile.

Ranking Table

RankCompanyCIKFull Filing SimilarityBusiness SimilarityRisk Factors SimilarityMD&A SimilarityMost Changed SectionAssessment
1BIOMERICA INC732900.9950.240.990.995Businesshigh
2GREYSTONE LOGISTICS, INC.10884130.990.9690.9920.963MD&Ahigh
3Stimcell Energetics Inc.14937120.9850.9990.9990.992MD&Ahigh
4Super Micro Computer, Inc.13753650.980.9810.9940.995Businessmedium
5CytoDyn Inc.11756800.9920.9980.9990.998MD&Alow

BIOMERICA INC

Rank1
Lowest similarity sectionBusiness
Assessmenthigh
SEC filings2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text)

Biomerica’s latest filing is much more focused on liquidity and financing than the prior year. Management now says cash is not enough to cover the next 12 months and that the company must raise more capital, even as it points to a new CDMO agreement and a post-year-end private placement as partial relief. The business section also highlights one-time ERC income and an investment gain, but those do not offset the core funding challenge.

Main Changes

  • The company now says its cash and cash equivalents fell to $1.3 million from $2.4 million, while working capital dropped to $1.5 million from $3.1 million, and it explicitly states these balances are insufficient for the next 12 months.
  • Management added stronger going concern language, saying there is "substantial doubt" about the company’s ability to continue as a going concern and that future viability depends on "securing additional financing" and achieving profitable operations.
  • The filing adds that Biomerica entered a Master Services Agreement for CDMO services with initial target fees exceeding $1.75 million and completed a private placement after year-end that raised about $2.23 million gross.
  • In Business, the company also disclosed a $1.1 million Employee Retention Credit benefit and a $335,000 unrealized gain on its Diagnosis S.A. investment, both new items not highlighted in the prior filing.

Watch Items

  • The going concern disclosure signals liquidity remains the central investment issue and that operating cash burn is still outpacing internal funding.
  • The CDMO contract and private placement suggest management is leaning on external revenue and capital raises to bridge near-term funding needs.
  • The new lease extension and Mexico renewal intent reduce facility uncertainty, but they do not materially change the broader cash pressure.

Important Filing Changes

2025 filing excerpt – Business

We target two main markets: (a) clinical laboratories and (b) point-of-care testing (physicians’ offices and over-the-counter drug stores). Our net sales were approximately $5,311,000 for fiscal year ended May 31, 2025, compared to $5,415,000 for fiscal year ended May 31, 2024. For the fiscal years ended May 31, 2025, and 2024, the Company had one distributor each year that accounted for 31% and 33% of our net sales, respectively.

2026 filing excerpt – Business

Dividend, Interest, and Other Income Dividend, interest, and other income was approximately $1,233,000 for the fiscal year ended May 31, 2026, compared to $165,000 for the fiscal year ended May 31, 2025, an increase of $1,068,000, or 648%. This increase was primarily attributable to $1,100,000 related to the Employee Retention Credit (“ERC”), a refundable payroll-tax credit established under the Coronavirus Aid, Relief, and Economic Security (“CARES”) Act.

2025 filing excerpt – Business

KEY PRODUCT LAUNCHES A key outcome from our research and development efforts is our patented diagnostic-guided therapy (“DGT”) product, developed on the inFoods® technology platform. This innovative technology is designed to aid in the management of gastrointestinal conditions such as irritable bowel syndrome (“IBS”) and other inflammatory diseases. The DGT product targets chronic inflammatory illnesses that are widespread and prevalent in large markets.

2026 filing excerpt – Business

Dividend, Interest, and Other Income Dividend, interest, and other income was approximately $1,233,000 for the fiscal year ended May 31, 2026, compared to $165,000 for the fiscal year ended May 31, 2025, an increase of $1,068,000, or 648%. This increase was primarily attributable to $1,100,000 related to the Employee Retention Credit (“ERC”), a refundable payroll-tax credit established under the Coronavirus Aid, Relief, and Economic Security (“CARES”) Act. The ERC was available to eligible employers for wages paid during calendar year 2021 in response to the global COVID-19 pandemic.

2025 filing excerpt – Risk Factors

PROPERTIES The Company leases its facilities. On May 31, 2025, the Company had approximately 22,000 square feet of floor space at its corporate headquarters at 17571 Von Karman Avenue in Irvine, California, 92614 which it has been leasing since 2009. This lease was scheduled to expire on August 31, 2016, but the Company had an option to extend the term of its lease for two additional sixty-month periods.

2026 filing excerpt – Risk Factors

Risk Factors in this Annual Report on Form 10-K . PROPERTIES On May 31, 2026, we had approximately 22,000 square feet of floor space at our corporate headquarters in Irvine, California, which we have been leasing since 2009. The initial lease term extended through August 31, 2026 and included an additional five-year extension option.

GREYSTONE LOGISTICS, INC.

Rank2
Lowest similarity sectionMD&A
Assessmenthigh
SEC filings2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text)

Greystone’s latest filing adds explicit going concern review language, which is a meaningful step up in financial risk disclosure. It also shows lenders requiring stronger personal support from management and a property transaction that is being treated as financing rather than a true sale. Taken together, the changes point to a company focused on liquidity management and debt support.

Main Changes

  • MD&A adds a new "Going Concern Assessment" section saying management now evaluates whether conditions create "substantial doubt" about the company’s ability to continue as a going concern within one year.
  • The new disclosure says the assessment now weighs operating results, liquidity, working capital, debt maturities, covenant compliance, forecasted cash flows, and "anticipated capital raising activities" and financing arrangements.
  • The filing also says adverse developments such as weaker operating performance, delays in financing, or an inability to restructure or refinance debt could materially affect the company.
  • In the debt discussion, Warren F. Kruger’s prior limited guaranty was replaced with an unlimited guaranty, and the Warren F. Kruger Trust also signed a new unlimited guaranty; the company also describes a 2026 real estate sale-leaseback that it accounts for as a financing obligation, not a sale.

Watch Items

  • The going concern language is a clear liquidity warning and suggests investors should focus on cash generation, refinancing access, and covenant headroom.
  • Unlimited guaranties from the CEO and his trust indicate lenders wanted stronger support, which can signal tighter credit conditions and higher financing risk.
  • The financing-style treatment of the Bettendorf property transaction shows the company is using asset monetization to raise cash while keeping operational use of the property.

Important Filing Changes

2025 filing excerpt – MD&A

Management’s Discussion and Analysis of Financial Condition and Results of Operations. Cautionary Statement Regarding Forward-Looking Information This Annual Report on Form 10-K includes "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended.

2026 filing excerpt – MD&A

However, whether actual results and developments will conform to Greystone’s expectations and predictions is subject to a number of risks and uncertainties that could cause actual results to differ materially from those contained in the forward-looking statements, including those factors discussed under the section of this Form 10-K entitled “Risk Factors.” In addition, Greystone’s historical financial performance is not necessarily indicative of the results that may be expected in the future and Greystone believes that such comparisons cannot be relied upon as indicators of future performance. Critical Accounting Policies and Estimates General Management’s discussion and analysis of financial condition and results of operations are based upon the Company’s consolidated financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States of America (U.S. The preparation of these consolidated financial statements requires the Company to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues, and expenses.

2025 filing excerpt – MD&A

Actual results may differ from these estimates under different assumptions or conditions. The Company believes the following critical accounting policies affect its more significant judgments and estimates used in the preparation of its consolidated financial statements. Revenue Recognition Revenue is recognized at the point in time a good or service is transferred to a customer and the customer obtains control of that good or receives the service performed.

2026 filing excerpt – MD&A

The Company believes the following critical accounting policies affect its more significant judgments and estimates used in the preparation of its consolidated financial statements. Going Concern Assessment The Company evaluates, at each reporting period, whether conditions or events raise substantial doubt about its ability to continue as a going concern within one year after the date the financial statements are issued. This evaluation requires significant management judgment and involves the consideration of numerous factors, including operating results, liquidity, working capital levels, debt maturities, compliance with debt covenants, forecasted cash flows, anticipated capital raising activities, and other financing arrangements.

2025 filing excerpt – Business

In addition, Greystone outsources production for pallets produced by injection molding machines as necessary to accommodate overflow. Greystone’s injection molding machine production as of May 31, 2025 consists of the following: · 37” X 32” rackable pallet, · 40” X 32” rackable pallet, · 37” X 37” rackable pallet, · 44” X 56” can pallet, · 48” X 48” rackable pallet, · 48” X 40” rackable pallet, · 48” X 44” rackable pallet, · 48” X 40” nestable pallet with or without detachable runners, · 45” X 45” nestable pallet with or without detachable bottom deck, · 24” X 40” display pallet, · 48” X 40” monoblock (one-piece) pallet, · Half-barrel keg stackable pallet, · Slim keg stackable pallet, · 36” X 36” rackable pallet, · 48” X 45” monoblock pallet, · 48” X 45” drum pallet, and · 48”…

2026 filing excerpt – Business

In addition, Greystone outsources production for pallets produced by injection molding machines as necessary to accommodate overflow. Greystone’s injection molding machine production as of May 31, 2026 consists of the following: ● 37” X 32” rackable pallet, ● 40” X 32” rackable pallet, ● 37” X 37” rackable pallet, ● 44” X 56” can pallet, ● 48” X 48” rackable pallet, ● 48” X 40” rackable pallet, ● 48” X 44” rackable pallet, ● 48” X 40” nestable pallet with or without detachable runners, ● 45” X 45” nestable pallet with or without detachable bottom deck, ● 24” X 40” display pallet, ● 48” X 40” monoblock (one-piece) pallet, ● Half-barrel keg stackable pallet, ● Slim keg stackable pallet, ● 36” X 36” rackable pallet, ● 48” X 45” monoblock pallet, ● 48” X 45” drum pallet, and ● 48” X 40” mid duty pallet. ● 30” X 38” stand-up beer keg pallet, ● 48” X 40” one-piece, lightweight, full picture-frame pallet. The equipment was operated under contract with Jasper Rubber.

Stimcell Energetics Inc.

Rank3
Lowest similarity sectionMD&A
Assessmenthigh
SEC filings2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text)

Stimcell increased spending sharply in fiscal 2026, mainly to restart and advance the eBalance® Home redesign with ADM Tronics. The company still has no revenue and says the business remains in an early development stage, so the filing reads as a funding-and-development story rather than an operating turnaround. Losses widened and the going-concern risk remains in place.

Main Changes

  • MD&A says research and development costs jumped to $209,176 from $64,009, driven by the decision to redesign the eBalance® Home device into a "compact, affordable consumer unit optimized for home use."
  • The company added that it engaged ADM Tronics Unlimited, Inc. in February 2025 to work on the redesign, whereas the prior year said development had been "temporarily abandoned" because of a lack of funding and an unfavorable financial position.
  • General and administrative expenses rose to $382,560 from $213,452, with corporate communications increasing to $276,223 from $133,436 and higher filing, office, and audit costs.
  • The company reported a larger net loss of $895,375 versus $566,293, while still stating it generated no revenue and has no revenue-generating activities tied to eBalance®.

Watch Items

  • The redesign effort signals management is still trying to commercialize the platform, but it also implies more cash burn before any revenue is possible.
  • The continued going-concern warning and larger accumulated deficit of $11,756,931 underscore dependence on new equity or debt financing.
  • Higher corporate communications spending may indicate a push to support financing, promotion, or market visibility rather than operating scale.

Important Filing Changes

2025 filing excerpt – MD&A

Operating Expenses During the year ended May 31, 2025, the Company’s operating expenses increased by 94.6% from $268,352 incurred during the year ended May 31, 2024, to $522,106 incurred during the year ended May 31, 2025. The most significant changes were as follows : · Research and development fees for the year ended May 31, 2025, increased by $86,548, or 384.0%, from a recapture of $22,539 incurred during the year ended May 31, 2024, to $64,009 the Company incurred during the year ended May 31, 2025. The increase in research and development fees during the year ended May 31, 2025, was associated with the Company’s decision to redesign the eBalance® Home device into a compact, affordable consumer unit optimized for home use, which resulted in an engagement of ADM Tronics Unlimited, Inc., a leader in electronic medical device engineering, who…

2026 filing excerpt – MD&A

Operating Expenses During the year ended May 31, 2026, the Company’s operating expenses increased by 58.2% from $522,106 incurred during the year ended May 31, 2025, to $826,027 incurred during the year ended May 31, 2026. The most significant changes were as follows : · General and administrative expenses for the year ending May 31, 2026, increased by $169,108, or 79.2%, from $213,452 during the year ending May 31, 2025, to $382,560 during the year ending May 31, 2026. The main driver of this change was a $142,787 increase in corporate communications, which rose to $276,223 in the current year from $133,436 in the prior year.

2025 filing excerpt – MD&A

During the comparative year ended May 31, 2024, the development of the eBalance® devices was suspended due to a lack of funding and unfavorable financial position. · During the year ended May 31, 2025, management fees increased to $90,000, as compared to $37,500 the Company incurred during the year ended May 31, 2024. · Consulting fees for the year ended May 31, 2025, increased by $7,532, or 5.8%, from $129,956 incurred during the year ended May 31, 2024, to $137,488 incurred during the year ended May 31, 2025. · General and administrative expenses for the year ended May 31, 2025, increased by $97,099, or 83.5%, from $116,353 incurred during the year ended May 31, 2024, to $213,452 incurred during the year ended May 31, 2025. The largest factors that contributed to this change were associated with a $130,065 increase in…

2026 filing excerpt – MD&A

The most significant changes were as follows : · General and administrative expenses for the year ending May 31, 2026, increased by $169,108, or 79.2%, from $213,452 during the year ending May 31, 2025, to $382,560 during the year ending May 31, 2026. The main driver of this change was a $142,787 increase in corporate communications, which rose to $276,223 in the current year from $133,436 in the prior year. Other notable changes included a $10,556 increase in filing and regulatory fees to $29,261 (May 31, 2025 – $18,705), a $7,741 increase in office expenses to $10,929 (May 31, 2025 – $3,188), and an $11,635 rise in accounting and audit fees to $57,936 (May 31, 2025 – $46,301).

2025 filing excerpt – Business

Due to the Company’s financial situation, during the year ended May 31, 2023, the Company suspended further research of the eBalance® Technology, including the PMA process for 510(k) clearance, and defaulted on its Health Canada Class II Medical Device System Certification licenses, which were suspended on June 5, 2023. In February of 2025, the Company established a new partnership with ADM Tronics Unlimited, Inc., a leader in electronic medical device engineering, with an aim to redesign the eBalance® Home device into a compact, affordable consumer unit optimized for home use, complete with cutting-edge diagnostic features. The redesigned eBalance® is being designed to be smaller and more cost-efficient than its predecessors, making advanced microcurrent technology accessible to a broader audience.

2026 filing excerpt – Business

Due to the Company’s financial situation, during the year ended May 31, 2023, the Company suspended further research of the eBalance® Technology, including the PMA process for 510(k) clearance, and defaulted on its Health Canada Class II Medical Device System Certification licenses, which were suspended on June 5, 2023. In February of 2025, the Company engaged ADM Tronics Unlimited, Inc., a leader in electronic medical device engineering, to redesign the eBalance® Home device into a compact, affordable consumer unit optimized for home use, complete with diagnostic features. The new eBalance® Home system is expected to be redesigned as a smaller and more cost-efficient unit than its predecessor, making advanced microcurrent technology accessible to a broader audience.

Super Micro Computer, Inc.

Rank4
Lowest similarity sectionBusiness
Assessmentmedium
SEC filings2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text)

Super Micro’s new filing adds a more specific tax-risk disclosure around its Malaysia expansion, saying a key manufacturing tax holiday is still pending and could disappear if conditions are not met. It also broadens the discussion of global tax law changes and makes clear that common stockholders should not expect dividends. Overall, the update points to higher tax uncertainty but no major change in operating strategy.

Main Changes

  • The company added a new risk that its Malaysian manufacturing tax incentive is not yet approved and could be lost if it misses conditions by December 16, 2026, which would leave income taxed at the statutory rate instead of a 10-year exemption.
  • It expanded tax-risk disclosure to say global tax changes, including the OECD Pillar Two framework and the U.S. One Big Beautiful Bill Act, could alter effective tax rates, deferred tax assets, and cash tax obligations.
  • The filing now states more directly that the company does not expect to pay cash dividends in the foreseeable future, except for the 7.00% dividend on its Mandatory Convertible Preferred Stock.

Watch Items

  • The Malaysian incentive matters because it could be a meaningful margin and cash-tax tailwind for a growing manufacturing base; losing it would pressure earnings and cash flow.
  • The broader tax language signals more sensitivity to changing international tax rules, which can add volatility to reported results and planning assumptions.
  • The dividend statement reinforces that common shareholders should not expect income support, so the stock remains a pure capital-appreciation story.

Important Filing Changes

2025 filing excerpt – Business

Business Our Company We are a Silicon Valley-based provider of total IT solutions which address demanding workloads from the enterprise and cloud to the intelligent edge. We deliver rack-scale solutions optimized for various workloads, including artificial intelligence (“AI”) and high-performance computing (“HPC”), where acceleration is critical and we also produce an extensive portfolio of server and storage solutions for enterprise data centers, cloud service providers, and edge computing (5G Telco, Retail and embedded).

2026 filing excerpt – Business

Business Our Company We are a Silicon Valley-based provider of total information technology ("IT") solutions which address demanding workloads from the enterprise and cloud to the intelligent edge. We deliver rack-scale solutions optimized for various workloads, including artificial intelligence (“AI”) and high-performance computing (“HPC”), where acceleration is critical.

2025 filing excerpt – Business

Business Our Company We are a Silicon Valley-based provider of total IT solutions which address demanding workloads from the enterprise and cloud to the intelligent edge. We deliver rack-scale solutions optimized for various workloads, including artificial intelligence (“AI”) and high-performance computing (“HPC”), where acceleration is critical and we also produce an extensive portfolio of server and storage solutions for enterprise data centers, cloud service providers, and edge computing (5G Telco, Retail and embedded). Our Total IT Solutions encompass complete servers, storage systems, modular blade servers, workstations, full-rack scale solutions, networking devices, server sub-systems, server management and security software.

2026 filing excerpt – Business

Business Our Company We are a Silicon Valley-based provider of total information technology ("IT") solutions which address demanding workloads from the enterprise and cloud to the intelligent edge. We deliver rack-scale solutions optimized for various workloads, including artificial intelligence (“AI”) and high-performance computing (“HPC”), where acceleration is critical. Additionally, we offer an extensive portfolio of server and storage solutions for enterprise data centers, cloud service providers ("CSPs"), and edge computing applications, such as 5G Telco, Retail and embedded.

2025 filing excerpt – Risk Factors

You should not interpret our disclosure of any of the following risks to imply that such risks have not already materialized. Risk Factor Summary The following is a summary of the most significant risks and principal factors that make an investment in our common stock speculative or risky. Risks Related to our Delinquent SEC Reporting Obligations • Circumstances discussed in the Explanatory Note in this Annual Report; • Our failure in timely filing our SEC reports; • The outcome of litigation and other legal proceedings, disputes, claims, as well as regulatory examinations, investigations, proceedings and orders arising out of the circumstances discussed in the Explanatory Note in this Annual Report, and any orders, actions or rulings not in our favor; • Significant expenses related to the circumstances discussed in the Explanatory Note in this Annual Report; • The remediation of…

2026 filing excerpt – Risk Factors

You should not interpret our disclosure of any of the following risks to imply that such risks have not already materialized. Risk Factor Summary The following summarizes the principal factors that make an investment in the Company speculative or risky. This summary should be read in conjunction with the remainder of this “Risk Factors” section and should not be relied upon as an exhaustive summary of the material risks facing our business.

CytoDyn Inc.

Rank5
Lowest similarity sectionMD&A
Assessmentlow
SEC filings2026 10-K HTML/iXBRL (SEC page, raw text) | 2025 10-K HTML/iXBRL (SEC page, raw text)

CytoDyn’s filing is mostly a housekeeping update, with the biggest structural addition being a new disclosure item about foreign jurisdictions that prevent inspections. The business section also shows a small increase in employees and an updated R&D expense figure, but the company’s strategy and operating setup are essentially unchanged. It still depends on outside manufacturers for leronlimab and says it is continuing to look for alternative CMC partners.

Main Changes

  • Added a new Item 9C, "Disclosure Regarding Foreign Jurisdictions That Prevent Inspections," to the table of contents, which was not present in the prior filing.
  • Updated the business section to say the company had 14 employees as of July 31, 2026, versus 13 employees as of June 30, 2025, indicating a small headcount increase.
  • Revised the research and development expense disclosure to show approximately $15.7 million for fiscal 2026 versus $(16.9) million for fiscal 2025, replacing the prior year comparison in the business section.
  • Kept the core operating model unchanged: CytoDyn still says it does not own manufacturing facilities, relies on third-party CMOs, and continues to seek alternative CMC partners for leronlimab.

Watch Items

  • The new foreign-inspection item may reflect a compliance or disclosure requirement that investors should monitor for any jurisdictional or regulatory friction.
  • The slight increase in headcount suggests modest operational build-out, but not a major shift in scale.
  • Ongoing dependence on third-party manufacturing remains a key execution risk because commercialization still hinges on outside CMO capacity and validation.

Important Filing Changes

2025 filing excerpt – Business

The Company is a clinical-stage biotechnology company focused on the clinical development of innovative treatments for multiple therapeutic indications based on its product candidate, leronlimab (also referred to as PRO 140), a novel humanized monoclonal antibody targeting the C-C chemokine receptor type 5 (“CCR5”). The pre-clinical and early clinical development of PRO 140 was led by Progenics through 2011. The Company acquired the asset from Progenics in October 2012.

2026 filing excerpt – Business

The Company is a clinical-stage biotechnology company focused on the clinical development of innovative treatments for multiple therapeutic indications based on its product candidate, leronlimab (also referred to as PRO 140), a novel humanized monoclonal antibody targeting the C-C chemokine receptor type 5 (“CCR5”). The preclinical and early clinical development of PRO 140 was led by Progenics through 2011. The Company acquired the asset from Progenics in October 2012.

2025 filing excerpt – Business

BUSINESS Corporate History/Business Overview CytoDyn Inc. (together with its wholly owned subsidiary, the “Company”) was originally incorporated under the laws of Colorado on May 2, 2002, under the name RexRay Corporation and, effective August 27, 2015, reincorporated under the laws of Delaware. The Company is a clinical-stage biotechnology company focused on the clinical development of innovative treatments for multiple therapeutic indications based on its product candidate, leronlimab (also referred to as PRO 140), a novel humanized monoclonal antibody targeting the C-C chemokine receptor type 5 (“CCR5”). The pre-clinical and early clinical development of PRO 140 was led by Progenics through 2011.

2026 filing excerpt – Business

Business Overview The Company is a clinical-stage biotechnology company focused on the clinical development and potential commercialization of its product candidate, leronlimab, which is being studied for its potential in solid-tumor oncology. Leronlimab targets CCR5, a receptor increasingly recognized for its role in tumor progression, metastasis and immune regulation, providing the Company with the opportunity to explore a potentially differentiated therapeutic approach across multiple solid tumor indications. Our current business strategy is to continue to pursue the clinical development of leronlimab, which may include the following: 1.

2025 filing excerpt – MD&A

Food and Drug Administration (the “FDA”) and, potentially, drug regulatory agencies in other countries; (ii) the Company’s ability to raise additional capital to fund its operations; (iii) the Company’s ability to meet its debt and other payment obligations; (iv) the Company’s ability to recruit and retain key employees; (v) the Company’s ability to enter into or maintain partnership or licensing arrangements with third parties; (vi) the timely and sufficient development, through internal resources or third-party consultants, of analyses of the data generated from the Company’s clinical trials required by the FDA or other regulatory agencies in connection with applications for approval of the Company’s drug product; (vii) the Company’s ability to achieve approval of a marketable product; (viii) the design, implementation and conduct of clinical trials; (ix) the results of any such clinical trials, including the possibility of unfavorable clinical…

2026 filing excerpt – MD&A

EXHIBITS AND FINANCIAL STATEMENT SCHEDULES 75 ITEM 16. FORM 10‑K SUMMARY 77 2 FORWARD-LOOK ING STATEMENTS This annual report contains certain forward-looking statements that involve risks, uncertainties and assumptions that are difficult to predict. Words and expressions reflecting optimism, satisfaction or disappointment with current prospects, as well as words such as “believes,” “intends,” “estimates,” “expects,” “projects,” “plans,” “anticipates” and variations thereof, or the use of future tense, identify forward-looking statements, but their absence does not mean that a statement is not forward-looking.

Why SEC Filing Changes Matter

Research by Cohen et al. (Lazy Prices, 2020) — using the complete history of SEC filings from 1995 to 2014 — shows that when firms make active changes to their annual disclosures, those changes convey an important signal about future operations and returns. A portfolio that shorted "changers" and bought "non-changers" earned over 22% per year in annual alpha historically. Changes to the Risk Factors section, Business description, and language referring to the executive team were especially informative. Critically, these returns accrued gradually as information was later revealed through news and earnings — not at the time of filing — suggesting many investors remain inattentive to these simple, public signals. This snapshot is a starting point for deeper investigation, not a buy or sell recommendation.

For more like this, see the full SEC What Changed archive, browse more equity research reports, or subscribe to Quantitative Research Notes for new filing-change alerts as soon as they publish.

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This material is provided for research and educational purposes only. It is not investment advice, a recommendation, or an offer to buy or sell any security or strategy.

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